Immuno-Oncology Research
Breakthroughs begin with understanding.
Understanding the tumor microenvironment is transforming immuno-oncology. Vector Laboratories provides the integrated biology, chemistry, and scientific expertise that help researchers generate reliable tissue insights—from sample preparation through translational validation. With end-to-end workflow support for immunohistochemistry (IHC), immunofluorescence (IF), and more, Vector Laboratories has the application solutions you need to break through.
Supporting Your Immuno-Oncology Research Goals
Behind every immuno-oncology question is a patient whose immune response is entirely their own. Answering it means interrogating how each tumor uniquely operates. The tissues, markers, and detection method all shape the workflow decisions that follow. Tap a card to see the workflow, sample type, and typical research question behind it.
High-plex IF / Spatial
Characterize tumor microenvironment
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Everything you need to characterize immune cell interactions in tissue
IHC
Checkpoint phenotyping
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Characterize immune checkpoint protein expression with confidence
ELISA
Biomarker validation
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What you need to move candidate biomarkers toward clinical confidence
Flow cytometry
Immune profiling
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Evaluate immune heterogeneity and predict treatment responses
Syngeneic / in vivo
Preclinical efficacy
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Move your discoveries toward therapeutic confidence
ADC / bispecific
Therapeutic development
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Biology and chemistry expertise to craft molecules and modalities for your specific target
Cancer Research Workflow Solutions
From highly characterized reagents to bespoke scientific services, Vector Laboratories helps you build and customize end-to-end immuno-oncology workflows, so you get definitive answers to your specific tumor interrogation questions.
Vector Laboratories combines biology, chemistry, antibodies, detection technologies, glycobiology, bioconjugation, and custom scientific services to support tissue-based immuno-oncology workflows—from target identification through translational validation and into therapeutic development.
Explore our end-to-end application workflow solutions for IHC, IF, and ELISA below.
Select your workflow:
Multiplex IF
Single-Plex IHC
Multiplex IHC
ELISA
Multiplex IF Workflow
1
Sample prep
2
Blocking
3
Primary antibody
4
Detection
5
Mounting medium
6
Antibody removal
Sample prep
Start with intact tissue. Our reagents keep sections fixed and antigens accessible.
Blocking
Clean background, true signal. Serum blocking suppresses non-specific staining.
Primary antibody
Trust every target. Characterized antibodies give reproducible staining and precise localization.
Detection
Signal, not autofluorescence. TrueVIEW quenching clears background for clean imaging.
Mounting medium
Protect your samples. VECTASHIELD media lock in fluorescence for bright, analysis-ready slides.
Antibody removal
Get more data from your section. Gentle stripping maintains tissue integrity round after round of staining.
1
Sample prep
2
Blocking
3
Primary binder
4
Detection
5
Chromogen
6
Counterstain & mount
Sample prep
Start with intact tissue. Our reagents keep sections fixed and antigens accessible.
Blocking
Clean background, true signal. Serum blocking suppresses non-specific staining.
Primary binder
Specificity you can defend. Characterized antibodies and lectins deliver reproducible staining.
Detection
Amplify true signal. ImmPRESS reagents and secondary antibodies enable precise visualization of low abundance targets.
Chromogen
Stain with confidence. Achieve crisp and sensitive staining with high-performance chromogenic substrates.
Counterstain & mount
Add context that lasts. Counterstain for architecture, mount for archive-stable slides.
1
Sample prep
2
Blocking
3
Primary antibody
4
Detection
5
Chromogen
6
Antibody removal & mount
Sample prep
Start with intact tissue. Our reagents keep sections fixed and antigens accessible.
Blocking
Clean background, true signal. Serum blocking suppresses non-specific staining.
Primary antibody
Confident on every marker. Characterized antibodies deliver reproducible multi-target signal.
Detection
Sensitive signal per marker. ImmPRESS polymers amplify the targets that matter.
Chromogen
Stain with confidence. Achieve crisp and sensitive staining with high-performance chromogenic substrates.
Antibody removal & mount
More markers, same tissue. Gentle removal enables sequential staining, then mounting.
1
Blocking
2
Primary binder
3
Detection
4
Substrate
Blocking
Detect accurately. BSA, casein, and carbo-free blockers keep signal specific.
Primary binder
Detect and quantify with confidence. Characterized antibodies and lectins anchor sensitive, reproducible assays.
Detection
Amplify reliably. Conjugated secondaries and ABC systems give consistent readouts.
Substrate
Consistent, comparable data. TMB delivers reproducible colorimetric signal every run.
Prefer an all-in-one?
Quick, cost-effective readout. Validated kits are ready-to-use for reproducible results.
Need a more customized solution? Our specialists can help you build end-to-end immuno-oncology workflows unique to your specific research and development questions.
Featured Cancer Research Areas
Our high-quality antibodies and reagents support cancer research across multiple applications, enabling the study of key biomarkers and pathways in breast cancer, colorectal cancer, lung cancer, and melanoma. Explore how our products advance research in these featured cancer types.
Breast Cancer
Labeling specific markers is crucial for breast cancer research, from tumor characterization to therapy selection and mechanistic studies. HER2, ER, and PR stratify standard subtypes, while Ki-67 and TP53 assess proliferation and invasion. In triple negative breast cancer, immunodetection-based tools support research on BRCA mutations and PD-L1 expression, informing immunotherapy eligibility.
Colorectal Cancer
Colorectal carcinoma (CRC) affects 4% of the population, requiring reliable reagents for diagnostics and therapy development. MSI-H and dMMR status, assessed via MLH1, MSH2, MSH6, and PMS2, identify patients eligible for immunotherapy. Antibodies also support biomarker research on CEACAM5 and targets for therapies like EGFR and VEGF inhibitors.
Lung Cancer
Lung cancer remains a leading cause of cancer deaths, with accurate biomarker detection critical for classification and treatment. Tissue-specific markers like TTF-1 and p63 help subtype tumors, while EGFR, ALK, and PD-L1 guide targeted therapies. Frequent mutations in KRAS, BRAF, and TP53 further shape lung cancer progression.
Melanoma
Immune checkpoint biology defines melanoma research, requiring precise markers for both diagnosis and immunotherapy response. BRAF, NRAS, and KIT mutations guide targeted therapy selection, while SOX10 and S100 support diagnostic subtyping. Checkpoint markers PD-L1, CTLA-4, and LAG-3 remain central to evaluating immunotherapy response and resistance.
One Supplier Across Biology, Chemistry, and the Science in Between.
Vector Laboratories is a leading provider of trusted immunodetection reagents and creator of bespoke molecules. Between off-the-shelf solutions trusted by thousands of researchers and in-house expertise in chemical synthesis, antibody engineering, and bioconjugation, Vector Laboratories bridges the gap between immuno-oncology discovery and impact.
Biology
More than 50 years of immunodetection expertise, with antibodies, blocking reagents, and detection chemistries validated across applications.
Chemistry
Linkers, fluorescent dyes, specialty chemistries, bioconjugation reagents, and kits designed for complex scientific applications.
Custom Services
Antibody sequencing, antibody engineering, protein expression, custom conjugation, and chemistry synthesis.
Scientific Partnership
Consultation from scientists who help you plan the workflow, with partnership flexibility, from custom components to scalable manufacturing.
Technical and Educational Cancer Research Resources
For more information on how Vector’s portfolio of products supports cancer research, explore the following resources.
Synergistic Strategies for Biologic Design and Functionalization
This approach to biologic design uses antibody engineering and modular chemistries to create adaptable, easy-to-optimize bioconjugates for fast iteration of experimental tools in complex biologic programs.
Multiplex IHC Protocol on Automated Stainers with VectaPlex™
The VectaPlex Antibody Removal Kit can be used on automated staining platforms for high-plex immunostaining while preserving tissue morphology and antigen integrity.
BioDesign: The Definitive Toolbox for
Optimizing Bioconjugate Properties and
Expediting Conjugate Synthesis
The BioDesign Toolbox provides drug developers ease of access to trusted antibody engineering, crucial bioconjugation products, and unique linker IP for ADC development.
Examining Altered Glycobiology in Cancer eBook
This eBook will walk you through a brief background and research being performed to empower you to unlock deeper insights in your cancer investigation with glycobiology.
Vector Laboratories in Immuno-Oncology
Read recent publications utilizing Vector Laboratories’ suite of antibodies, lectins, and immunodetection reagents support immuno-oncology applications and can take research from the bench to the clinic.
Immune-Evasion Target Atlas
However a tumor evades the immune system, the question for your research is the same: can you see it in the tissue? Explore the immuno-oncology (IO) target landscape, then build the IHC/IF workflow to detect it.
Ready to Advance Your Immuno-Oncology Workflows?
Tell us what you’re trying to characterize, validate, or build, and our experts will build a custom workflow for your unique project needs.
